Click here to download Happ E Mare Protocol

A great tasting supplement for your mare – you will have no troubles feeding this product.
Unique Combinations Of:
1.Herbs- Eleuthro, ashwagandha, chastetree berry, USDA certified organic raspberry leaf, ginger, oregano, spirulina, chia, Boswellia, arginine, MSM.
2.Added Vitamins to help mares
• Vitamin B6 – 2mg a dose
• Vitamin E – 2024 IU a dose
Safe: Tested Negative For – Salmonella, E.Coli & Listeria at University of Pennsylvania Veterinary School, Diagnostics Lab.
Safe: Tested Negative For – herbicides, drugs and lead at University of Pennsylvania Veterinary School, Diagnostics Lab.
Non-GMO – see separate sections on this site about why this is important.
Gluten Free
Contains no added selenium – tested selenium negative.
Special USDA certified organic raspberry leaf – see separate section on this site about why this is important.
Tested Free of aflatoxins – at Midwest Labs.
Tested low sugar, low carb (March 2018)– at equi-analytical labs:
• WSC= 2.3
• ESC= 2.0
• Starch= .2
Mineral Screen
•From University of Pennsylvania Veterinary School, Diagnostics Lab. • Lead, Arsenic, Thallium Free • Per Scoop:

HAPP-E Mare is the Winner!

Normal Estrous Cycle
1. Mares are “long day, seasonally polyestrous breeders.”
As the days get longer (more light in a 24 hour period), they start cycling. As the days get shorter (in the autumn), they stop cycling. Their cycle lasts spring, summer and early fall. In late fall and winter, the mare is in anestrous – there is no cycling. In the spring, they go through a transition phase, where they go from anestrus back to estrus cycling, This also occurs in the fall when they go out of estrus cycling.
These two transition phases will have an abnormal cycling times and that leads to a stressful time for mares – it can last for 60-80 days, but can be in and out of heat within only a few days for example.
The usual estrus and diestrus days are not on schedule. They are irregular in timing, making behavioral patterns erratic.
• Click here for Dr. Wolfsdorf’s article on Transition Periods in The Horse Magazine, 2016 2. In anestrus (late Fall & Winter), even though mares are not cycling, they often will have behavioral problems. They may be mildly receptive to a stallion still or even be fully receptive all winter.
3. Polyestrous means they will have many cycles during the long day times of the year – each estrus cycle is 21 days long.
• For 4-6 days, a follicle forms on an ovary during estrus and mares are receptive to a stallion.
• For 16-17 days, the mare is in diestrus where the corpus luteum forms on the ovary and the mare is not receptive to a stallion.
• Click here for Dr. Sertich’s article on the Reproductive Cycle of the Horse in the Merck Veterinary Manual.
4. Control of estrus depends on control of hormones. In estrus, the main hormone is estrogen. In diestrus, the main hormone is progesterone.
• Click here for in depth info on mare cycles from Ontario Department of Agriculture.•

Mares are different from humans.
1. Mares will continue to have cycles in estrous throughout their lives – there is NO menopause for mares!
2. Mares do not menstruate. Often you will see products with “PMS Formula” – technically this is not true since mares can not get PMS. Some mares do have many of the signs of PMS, but it’s important for owners to know this difference.

Insulin resistance will cause inability of the mare to get pregnant, can cause foal loss (abortion) or laminitis in the late stages of pregnancy.
If your mare is prone to IR via genetics or eating patterns/diet, it can affect their behavior and estrus cycle pattern.
Click here to visit the Insulin Resistance section of our website to see how to help avoid IR.
* Heiro is used to get pregnant, stay pregnant, and avoid laminitis in insulin resistant mares.

Often owners will comment that their mare started a laminitis bout when she started coming into heat. Why is this happening?
1.These mares are already IR (insulin resistant) and are on the edge of high blood insulin creating laminitis – the start of their heat cycle is the final push over the cliffs edge.
2.There are several studies showing high amounts of estrogen can trigger insulin resistance – in mare going into heat, estrogen levels are increasing and peaking. The exact mechanism of estrogen’s effect on insulin resistance are still being studied (some studies conflict on findings), but here are 3 studies showing estrogen’s ability to add to insulin resistance.
A. Insulin Sensitivity is Decreased in Normal Women on Estradiol Doses.
1. Estradiol supplemented decreases insulin sensitivity.
2. This effect was not in all subjects.
3. Note from Dr. Reilly: “This must suggest that this effect will not occur in all mares”.
Click Here to view Dr. Kojima’s article on mayDecreased Insulin Sensitivity B. Effect of Estrogen on Insulin Sensitivity.
1. Moderate estrogen doses may actually increase insulin sensitivity, but higher doses of it creates Insulin Resistance.
2. Note from Dr. Reilly: “Estrogen peaks early in heat cycle might be when we see problems in sore mares that are IR/prone to estrogen peak hyperinsulin”. Click Here to view Dr. Lindheim’s article on the Effect of Estrogen on Insulin Sensitivity
C. Estrogen Given to Men Induced Insulin Resistance.
1. 18 men given high dose estradiol.
2. Estradiol treatment in men can induce insulin resistance in healthy subjects.
3. Note from Dr. Reilly: “Using this hormone in a male and creating IR is strong evidence of estrogen having a role in insulin action”.
Click Here to View Dr. Polderman’s article on the Induction of Insulin Resistance.
* Mares that are already IR are more prone to hormone shifts/stress D. Stress of Coming into Heat
1. Stress raises cortisol and that hormone interferes with normal insulin action, which creates a insulin surge to overcome this interference. If already IR, becomes very IR and laminitis triggered

Low Thyroid Hormone – many mares will benefit from a combination of Happ-E-Mare and ThyroL powder. Have your vet test the mare’s total T4 level. Often, they are SUBOPTIMAL and run at the bottom of the normal range – we need them at the top of the normal range.
1-2 scoops (12-24 mg) of ThyroL can help bring your mare to the top of the normal range for optimal immunity and muscle health.
Example:
Test #1 T4 = 1.3 (where the normal range is 1-3)
Test #2 T4 on ThyroL = 2.7 (top of normal range)
On tests, DO NOT ACCEPT “it’s normal” – we know that.
Think of it this way:
You get into a car accident and are taken to the hospital.
Dr. A is 1 year out of school and has license.
Dr. B is head of surgery, 30 years of experience, wrote 2 books on trauma and has license.
BOTH are normal, but you know who you would choose.

External Reproductive Tract Anatomy Problem
If your mare’s vulva tilts inward, manure has a tendency to pour out onto her reproductive tract, which leads to urinary tract infections. The mare might urinate more often, feel poorly and not really care if a stallion is around – this can lead to problems in gauging where she is in the estrus cycle. She may be resistant to being ridden and not be able to focus due to having an infection. These infections can also progress to uterine infections. Excess fluid and inflammatory cells build up in the uterus. Uterine infections lead to short cycling – the time out of heat is very short, so she is in heat more often.
Click here for Dr. Cook’s article on Mares and Hormones from The Horse Magazine, 2012.

1. Transition periods of abnormal estrus cycles – 60 days in spring and 60 days in fall
2. Hormonal swings of coming into heat – from progesterone to estrogen control There are approximately 11 estrus cycles a year, creating behavioral and physical changes in your mare.
3. Anestrus (“in heat”) abnormal issues – mare is NOT to be cycling then, but many mares exhibit “in heat” signs in the winter.

Often, horses do not have a hormonal problem but still need a calming aid for their nervousness. Happ-E-Mare can help them by reducing inflammation, helping immunity, easing their stomachs and supporting muscles so they feel better. Sometimes nervousness is caused by discomfort. Happ-E-Mare is good to use in both mares and geldings!

• Click here for the effects of Ginger: Dr. Mashhadi, International Journal of Preventive Medicine, 2013.
  a. The gingerol in ginger is a proven antioxidant and anti-inflammatory.
  b. Gingerol also is shown to reduce COX2 expression, so it also reduces prostaglandins.
• Click the link to see how ginger can protect neurons via anti-neuroinflammation. Dr. Park, Acta Pharmacologica Sinica, 2013.
• Click here to see how ginger reduced muscle soreness by 25% in a study by Dr. Black, Journal of Pain, 2010.
• Click here to see how ginger is an immune adaptogen that fights inflammation. Dr. Tripathi et al, BMC Complement Altern Med., 2008.

• Click here for Dr. Coccimiglio’s study in Oxidative Medicine and Cellular Longevity, 2016.
  a. Oregano is a cytotoxic protectant via antioxidative ability.
  b. Oregano also works as an antibacterial against multiple pathogenic bacteria such as pseudomonas and e. coli.

• Click here for Dr. Coccimiglio’s study in Oxidative Medicine and Cellular Longevity, 2016.
  a. Helps general liver function – reduced liver fats by 40%.
  b. Helps cardiovascular conditions
  c. Powerful antioxidant
  d. Helps in protecting and preventing environmental/chemical/heavy metal oxidative stress and inflammation

• Click here to see the effects of Vitamin E deficiency on fatigue and muscle contractile properties: Dr. Coombes, Journal of Applied Physiology, 2002.
  a. Insomnia and poor quality of sleep results in chronic sleep loss and metabolic disorders.
  b. Ashwagandha is proven to help induce sleep and quality of sleep.
• Click here to see how ashwagandha helps reduce stress and anxiety: Dr. Chandrasekhar, Indian Journal of Psychological Medicine, 2012.

  a. Ashwagandha is a safe and effective adaptogen.

  b. Proven to reduce stress and anxiety in study.

  c. Reduced stress blood control levels by 27.9%.

• Click here to see the effects of Vitamin E deficiency on fatigue and muscle contractile properties: Dr. Coombes, Journal of Applied Physiology, 2002.
  a. Vitamin E reduces oxidative damage
  b. Vitamin E deficiency showed a 69% reduction in muscle fatigue.
  c. A horse’s anxiety may be caused by muscle soreness from a Vitamin E deficiency.
• Click here for Dr. Tütüncü’s article in Diabetes Care, 1998.

  a. Nerve damage was reversed with Vitamin E supplementation and the nerves improved as well.
• Click here for Dr. Kamish’s article in Pharmaceutical Biology, 2014 about Vitamin E as a potential therapy for gastric mucosal injury.

  a. Vitamin E can help with stomach ulcers.

  b. Nervous horses have stomach problems – Vitamin E can help them feel better!

• Click here for Dr. Panossian’s article in Pharmaceuticals, 2010 on the effects of eleuthro’s adaptogens on the central nervous system.
  a. Eleuthro reduces anxiety as an anxiolitic, is anti-inflammatory, gastroprotective and helps cognitive performance (memory and learning).
  b. Also helps reduce stress and physical and mental fatigue.
• Click here for Dr. Kuo’s article in Chin J Physiology, 2010.

  a. Eleuthro helped in oxygenation of athletes by 12%.

  b. Eleuthro helped increased endurance capacity by 23%.

• Click here to see University of Michigan Health Library

1. “Reduced Nitric Oxide and Carbon Monoxide and oxidative changes.”
2. MSM shown to provide protection in humans for muscular skeletal pain, allergies and arthritis.
3. “MSM protects horse from exercise induced oxidative stress”
4. “Protective effect against oxidation and potential inflammation”

• Click Here for University study from Madrid – The Horse
• Click Here for University study from Madrid – The HorseClick Here for article in New Zealand Horse Talk

1. Horses getting MSM supplement showed less inflammation on thermography
2. Horses on MSM had better training times in race horses
3. Dr. Riegal concluded “MSM has significant anti-inflammatory and analgesic effects for horses.”

• Click Here for article from 2001 in The Horse

1. In a human study, energy levels increased and lower airway respiratory symptoms decreased

• Click Here for J. of Alt/Comp Medicine 2002 article by Dr. Barrager

1. MSM found in all plants
2. MSM scores decreased when on MSM
3. MSM showed protection in development of arthritis in the model

• Click Here Jap. Pharm/Therapeutics. 2004 article by Dr. Hasegawa

1. MSM sulfur content used by the body to maintain connective tissue
2. Adding MSM “produced improvement in performing activities of daily living” in humans with osteoarthritis of the knees
3. MSM showed protection in development of arthritis in the model

• Click Here study in osteoarthritis 2006 Dr. Kim

• Click Here to see Dr. Siddiqui’s, 2011 article in Indian Journal of Pharmacology

• Click Here to see Dr. Ammon’s, 2006 article in Planta Med

Can I use Happ-E-Mare in geldings or stallions with Behavioral Issues?

….But Happ-E-Mare is here to help!

1. Yes! Happ-E-Mare contains no prohibited herbs.
2. In many mare products on the market, you can NOT use them for 14 days prior to events.
3. Prohibited herbs in many mare products include:
   
   Click here for Herbs prohibited by FEI – Horsetalk, 2009.
4. Prohibited in competition, but it is listed in horse catalogs and online – Be Careful!

• Brand A – contains passion flower, chamomile
• Brand B – contains vervain, chamomile
• Brand C – contains passion flower, chamomile, valerian
• Brand D – contains valerian

Happ-E-Mare is tested free of all herbicides, pesticides, drugs and lead. You need this information to make fully informed decisions for your horses.

Happ-E-Mare is free of GMOs as well as gluten, and can be taken in conjunction with medications your mare may be prescribed to

1. Equianalytical Labs tested cut and sifted raspberry leaf and found it was high in ESC sugars – 8.5% – and extremely high in WSC (fructans) at 20.4%.

• Happ-E-Mare’s raspberry leaf is 100% organic – top grade, top quality and top safety.
• Herbicides with Raspberry Leaf. Happ-E-Mare tested negative for Herbicides. We make sure our source and amount of raspberry leaf is safe. With others, you may have no idea what types of herbicides, pesticides or chemicals the grower uses.
• Non-GMO Raspberry Leaf is in Happ-E-Mare. With others, you may have no idea whether the herb is GMO or non-GMO.
• Raspberry Leaf in Happ-E-Mare is USDA certified organic. Your horse deserves the best, and with others, you may have no idea if the herb is organic or not.

Regumate is a synthetic, progesterone-like oral hormone.
1.Problem #1: Regumate is prescription only. You can not get it at the store or online without a veterinary prescription. Happ-E-Mare is available in stores and online with no prescription.
2. Problem #2: Regumate is $2.50 per dose. Happ-E-Mare is only $0.95 a dose – if feeding over an 8 month period (spring to early fall), that’s $372 in savings!
3. Problem #3: Some mares have adverse reactions to Regumate. They can become more spooky, nervous or aggressive. Happ-E-Mare’s all natural formula works to calm mares.
4.Problem #4: Missing a dose of Regumate will result in your mare coming into heat. If you run out and skip a dose one or two times, your mare will come into heat. Restarting it will have no effect for at least a week. Happ-E-Mare will NOT cause hormonal crashes if a dose is missed.
5. Problem #5: Regumate is not approved in geldings. Happ-E-Mare is approved for use in geldings who need calming for better focus and better performance.
6. Problem #6: Regumate is synthetic and contains no added herbs, minerals or vitamins. Happ-E-Mare is made from natural herbs, minerals and vitamins.
7.Problem #7: Human contact with skin can result in hormonal imbalances in people. Regumate can be absorbed through the skin.
* You can give both Regumate and Happ-E-Mare together and then slowly wean off Regumate.
Click here for an extensive 2003 article by the Ontario Department of Agriculture on Accidental Exposure to Regumate
• Need “extreme caution when handling”
• “Acute effects after single exposure are possible.”
• “Protective clothing consisting of safety goggles, coveralls and special gloves.”
• “If on skin, consult a physician.”
Click here for the Regumate package insert
• Contraindicated in mares with previous or current history of uterine inflammation
• Pregnant or suspected pregnant women cannot handle
• Women with known or suspected carcinoma of the breast cannot handle
• Anyone with liver disease cannot handle
• Must store at or below 77 degrees Fahrenheit
Click here ti see July 2018 FDA warning about reproductive problems in people exposed to Regumate
• Adverse effects in women/girls
• 137 confirmed cases
• Long term exposure leads to suspected breast cancer

Happ-E-Mare:
No gloves or protective clothing needed.
Stable at hot or cold temperatures and has a 2 year shelf-life.
No problems with handling or if it gets on skin.

Does your Jenny (Female Donkey) get Moody?
1.Yes, she can use Happ-E-Mare! They have the same reproductive cycles as mares.
2 Happ-E-Mare can help them to be less anxious and nervous, and more comfortable.
3. Donkeys are more prone to Insulin resistance if miniature – you can use Happ-E-Mare and the Heiro program together!
4.Many Jennies have reproductive problems if IR. If you plan on breeding your donkey, discontinue use of Happ-E-Mare, but continue the Heiro program through pregnancy and nursing.

Happ-E-Mare has 9 natural herbs with no loss of potency from being processed with heat (200°F steamed heat) to produce a pellet. “Pellets are hot when they leave the pellet die because of heat coming from steam conditioning.”
Click here for an article on Equinews regarding pellet processing.
If Happ-E-Mare went through the extrusion process, it would cook the herbs at 260°F.